2KUG

Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM N-terminal domain

Summary for 2KUG

• Entry DOI: 10.2210/pdb2kug/pdb
• Related: 2KUH
• NMR Information: BMRB: 16764
• Descriptor: Calmodulin, CALCIUM ION, 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE (3 entities in total)
• Functional Keywords: calmodulin, calcium binding, volatile anesthetic, halothane, cytoskeleton, isopeptide bond, methylation, phosphoprotein, metal binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 8731.89

Authors

Juranic, N.,Macura, S.,Simeonov, M.V.,Jones, K.A.,Penheiter, A.R.,Hock, T.J.,Streiff, J.H. (deposition date: 2010-02-17, release date: 2010-03-09, Last modification date: 2020-02-05)

• Primary citation: Juranic, N.O.,Jones, K.A.,Penheiter, A.R.,Hock, T.J.,Streiff, J.H.; Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase.; J. Serb. Chem. Soc., 78:1655-1670, 2013

Experimental method

SOLUTION NMR