2K62

NMR solution structure of the supramolecular adduct between a liver cytosolic bile acid binding protein and a bile acid-based Gd(III)-chelate

Summary for 2K62

• Entry DOI: 10.2210/pdb2k62/pdb
• Related: 2JN3
• NMR Information: BMRB: 15854
• Descriptor: Liver fatty acid-binding protein, YTTERBIUM (III) ION, (3alpha,5alpha,8alpha)-3-[(N,N-bis{2-[bis(carboxymethyl)amino]ethyl}-L-gamma-glutamyl)amino]cholan-24-oic acid (3 entities in total)
• Functional Keywords: hepatospecific contrast agent, haddock, gd(iii) bile acid adduct, acetylation, cytoplasm, lipid-binding, transport, lipid binding protein
• Biological source: Gallus gallus
• Cellular location: Cytoplasm: P80226
• Total number of polymer chains: 1
• Total formula weight: 15096.20

Authors

Tomaselli, S.,Zanzoni, S.,Ragona, L.,Gianolio, E.,Aime, S.,Assfalg, M.,Molinari, H. (deposition date: 2008-07-03, release date: 2008-11-04, Last modification date: 2022-03-16)

• Primary citation: Tomaselli, S.,Zanzoni, S.,Ragona, L.,Gianolio, E.,Aime, S.,Assfalg, M.,Molinari, H.; Solution structure of the supramolecular adduct between a liver cytosolic bile acid binding protein and a bile acid-based gadolinium(III)-chelate, a potential hepatospecific magnetic resonance imaging contrast agent.; J.Med.Chem., 51:6782-6792, 2008; PubMed: 18939814; DOI: 10.1021/jm800820b

Experimental method

SOLUTION NMR