2ING

X-ray Structure of the BRCA1 BRCT mutant M1775K

Summary for 2ING

Entry DOI	10.2210/pdb2ing/pdb
Descriptor	Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION (3 entities in total)
Functional Keywords	zinc-finger, dna-binding, dna repair, disease mutation, phosphorylation, dna binding protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398
Total number of polymer chains	1
Total formula weight	24592.03
Authors	Birrane, G.,Soni, A.,Ladias, J.A.A. (deposition date: 2006-10-07, release date: 2007-09-04, Last modification date: 2023-08-30)
Primary citation	Tischkowitz, M.,Hamel, N.,Carvalho, M.A.,Birrane, G.,Soni, A.,van Beers, E.H.,Joosse, S.A.,Wong, N.,Novak, D.,Quenneville, L.A.,Grist, S.A.,Nederlof, P.M.,Goldgar, D.E.,Tavtigian, S.V.,Monteiro, A.N.,Ladias, J.A.,Foulkes, W.D. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur.J.Hum.Genet., 16:820-832, 2008 Cited by PubMed: 18285836 DOI: 10.1038/ejhg.2008.13 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation