2IF4

Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana

Summary for 2IF4

• Entry DOI: 10.2210/pdb2if4/pdb
• Related: 2F4E
• Descriptor: ATFKBP42 (2 entities in total)
• Functional Keywords: fkbp-like, alpha-beta, tpr-like, alpha, signaling protein
• Biological source: Arabidopsis thaliana (thale cress)
• Cellular location: Cell membrane; Single-pass membrane protein: Q9LDC0
• Total number of polymer chains: 1
• Total formula weight: 38364.39

Authors

Granzin, J.,Eckhoff, A.,Weiergraeber, O.H. (deposition date: 2006-09-20, release date: 2006-10-31, Last modification date: 2024-02-21)

Primary citation

Granzin, J.,Eckhoff, A.,Weiergraber, O.H.
Crystal Structure of a Multi-domain Immunophilin from Arabidopsis thaliana: A Paradigm for Regulation of Plant ABC Transporters.
J.Mol.Biol., 364:799-809, 2006

PubMed Abstract: FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 A resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.

PubMed: 17045295
DOI: 10.1016/j.jmb.2006.09.052

Experimental method

X-RAY DIFFRACTION (2.85 Å)