2HWA

Crystal structure of Lys12Thr/Cys117Val mutant of human acidic fibroblast growth factor at 1.65 angstrom resolution.

Summary for 2HWA

• Entry DOI: 10.2210/pdb2hwa/pdb
• Related: 1JQZ
• Descriptor: Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: beta-trefoil, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P05230
• Total number of polymer chains: 2
• Total formula weight: 33593.50

Authors

Dubey, V.K.,Lee, J.,Somasundaram, T.,Blaber, M. (deposition date: 2006-08-01, release date: 2007-06-12, Last modification date: 2023-08-30)

• Primary citation: Dubey, V.K.,Lee, J.,Somasundaram, T.,Blaber, S.,Blaber, M.; Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions.; J.Mol.Biol., 371:256-268, 2007; PubMed: 17570396; DOI: 10.1016/j.jmb.2007.05.065

Experimental method

X-RAY DIFFRACTION (1.65 Å)