2HB3

Wild-type HIV-1 Protease in complex with potent inhibitor GRL06579

Summary for 2HB3

Entry DOI	10.2210/pdb2hb3/pdb
Descriptor	Protease, CHLORIDE ION, SODIUM ION, ... (6 entities in total)
Functional Keywords	active-site cavity protease inhibitor catalytic aspartic acid, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
Total number of polymer chains	2
Total formula weight	22286.49
Authors	Kovalevsky, A.Y.,Weber, I.T. (deposition date: 2006-06-13, release date: 2006-08-29, Last modification date: 2024-02-14)
Primary citation	Ghosh, A.K.,Sridhar, P.R.,Leshchenko, S.,Hussain, A.K.,Li, J.,Kovalevsky, A.Y.,Walters, D.E.,Wedekind, J.E.,Grum-Tokars, V.,Das, D.,Koh, Y.,Maeda, K.,Gatanaga, H.,Weber, I.T.,Mitsuya, H. Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance. J.Med.Chem., 49:5252-5261, 2006 Cited by PubMed: 16913714 DOI: 10.1021/jm060561m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation