2H9T
Crystal structure of human alpha-thrombin in complex with suramin
Summary for 2H9T
Entry DOI | 10.2210/pdb2h9t/pdb |
Descriptor | Thrombin, PPACK active site thrombin inhibitor, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, ... (5 entities in total) |
Functional Keywords | thrombin, coagulation factor ii, suramin, inhibitor, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35593.53 |
Authors | Lima, L.M.T.R.,Polikarpov, I.,Monteiro, R.Q. (deposition date: 2006-06-11, release date: 2007-05-22, Last modification date: 2023-08-30) |
Primary citation | Lima, L.M.,Becker, C.F.,Giesel, G.M.,Marques, A.F.,Cargnelutti, M.T.,de Oliveira Neto, M.,Queiroz Monteiro, R.,Verli, H.,Polikarpov, I. Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases. Biochim.Biophys.Acta, 1794:873-881, 2009 Cited by PubMed: 19332154DOI: 10.1016/j.bbapap.2009.03.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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