2H2C

Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV)

Summary for 2H2C

Entry DOI	10.2210/pdb2h2c/pdb
Related	2H2B 2H3L 2H3M
Descriptor	Tight junction protein ZO-1 (2 entities in total)
Functional Keywords	pdz domain, phage derived high affinity ligand, cell adhesion
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side: Q07157
Total number of polymer chains	1
Total formula weight	11725.24
Authors	Appleton, B.A.,Zhang, Y.,Wu, P.,Yin, J.P.,Hunziker, W.,Skelton, N.J.,Sidhu, S.S.,Wiesmann, C. (deposition date: 2006-05-18, release date: 2006-06-13, Last modification date: 2023-08-30)
Primary citation	Appleton, B.A.,Zhang, Y.,Wu, P.,Yin, J.P.,Hunziker, W.,Skelton, N.J.,Sidhu, S.S.,Wiesmann, C. Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity. J.Biol.Chem., 281:22312-22320, 2006 Cited by PubMed: 16737969 DOI: 10.1074/jbc.M602901200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation