2GZ9

Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease

Summary for 2GZ9

• Entry DOI: 10.2210/pdb2gz9/pdb
• Related: 2GZ7 2GZ8
• Descriptor: Replicase polyprotein 1ab (2 entities in total)
• Functional Keywords: sars cov main protease, hydrolase
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 1
• Total formula weight: 33876.64

Authors

Lu, I.L.,Wu, S.Y. (deposition date: 2006-05-11, release date: 2006-08-29, Last modification date: 2023-10-25)

• Primary citation: Lu, I.L.,Mahindroo, N.,Liang, P.H.,Peng, Y.H.,Kuo, C.J.,Tsai, K.C.,Hsieh, H.P.,Chao, Y.S.,Wu, S.Y.; Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease; J.Med.Chem., 49:5154-5161, 2006; PubMed: 16913704; DOI: 10.1021/jm060207o

Experimental method

X-RAY DIFFRACTION (2.17 Å)