2G7H

Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)

Summary for 2G7H

Entry DOI	10.2210/pdb2g7h/pdb
NMR Information	BMRB: 7122
Descriptor	Methylated-DNA--protein-cysteine methyltransferase (1 entity in total)
Functional Keywords	protein structure, dna repair, dna methyltransferase, transferase
Biological source	Methanocaldococcus jannaschii
Cellular location	Cytoplasm (By similarity): Q58924
Total number of polymer chains	1
Total formula weight	19460.94
Authors	Roberts, A. (deposition date: 2006-02-28, release date: 2006-08-01, Last modification date: 2024-05-29)
Primary citation	Roberts, A.,Pelton, J.G.,Wemmer, D.E. Structural studies of MJ1529, an O(6)-methylguanine-DNA methyltransferase Magn.Reson.Chem., 44:71-82, 2006 Cited by PubMed Abstract: The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the thermophile Methanococcus jannaschii has been determined using multinuclear multidimensional NMR spectroscopy. The structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain. The C-terminal domain is more highly conserved in both sequence and structure. Regions of the protein show broadening, reflecting conformational flexibility that is likely related to function. PubMed: 16826543 DOI: 10.1002/mrc.1823 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation