2G00

Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide

Summary for 2G00

• Entry DOI: 10.2210/pdb2g00/pdb
• Descriptor: Coagulation factor X, 3-[6-{2'-[(DIMETHYLAMINO)METHYL]BIPHENYL-4-YL}-7-OXO-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN-1-YL]BENZAMIDE (3 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32569.88

Authors

Alexander, R.S. (deposition date: 2006-02-10, release date: 2006-10-03, Last modification date: 2017-10-18)

• Primary citation: Pinto, D.J.,Galemmo, R.A.,Quan, M.L.,Orwat, M.J.,Clark, C.,Li, R.,Wells, B.,Woerner, F.,Alexander, R.S.,Rossi, K.A.,Smallwood, A.,Wong, P.C.,Luettgen, J.M.,Rendina, A.R.,Knabb, R.M.,He, K.,Wexler, R.R.,Lam, P.Y.; Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties.; Bioorg.Med.Chem.Lett., 16:5584-5589, 2006; PubMed: 16963264; DOI: 10.1016/j.bmcl.2006.08.027

Experimental method

X-RAY DIFFRACTION (2.1 Å)