2FZZ

Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one

Summary for 2FZZ

Entry DOI	10.2210/pdb2fzz/pdb
Descriptor	Coagulation factor X, 1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-6-(2'-{[(3R)-3-HYDROXYPYRROLIDIN-1-YL]METHYL}BIPHENYL-4-YL)-3-(TRIFLUOROMETHYL)-1,4,5,6-TETRAHYDRO-7H-PYRAZOLO[3,4-C]PYRIDIN-7-ONE (3 entities in total)
Functional Keywords	glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00742 P00742
Total number of polymer chains	2
Total formula weight	32624.92
Authors	Alexander, R.S. (deposition date: 2006-02-10, release date: 2006-06-27, Last modification date: 2011-07-13)
Primary citation	Pinto, D.J.,Orwat, M.J.,Quan, M.L.,Han, Q.,Galemmo, R.A.,Amparo, E.,Wells, B.,Ellis, C.,He, M.Y.,Alexander, R.S.,Rossi, K.A.,Smallwood, A.,Wong, P.C.,Luettgen, J.M.,Rendina, A.R.,Knabb, R.M.,Mersinger, L.,Kettner, C.,Bai, S.,He, K.,Wexler, R.R.,Lam, P.Y. 1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. Bioorg.Med.Chem.Lett., 16:4141-4147, 2006 Cited by PubMed: 16730984 DOI: 10.1016/j.bmcl.2006.02.069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation