2F9V
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines
Summary for 2F9V
Entry DOI | 10.2210/pdb2f9v/pdb |
Related | 1A1R 1JXP 1N1L 2A4G 2A4Q 2A4R |
Descriptor | NS3 protease/helicase, polyprotein, ZINC ION, ... (5 entities in total) |
Functional Keywords | hcv, hepatitis c protease, ns3 protease, ketoamide inhibitor, viral protein |
Biological source | Hepatitis C virus More |
Total number of polymer chains | 4 |
Total formula weight | 48200.27 |
Authors | Bogen, S.L.,Ruan, S.,Liu, R.,Agrawal, S.,Pichardo, J.,Prongay, A.,Baroudy, B.,Saksena, A.,Girijavallabhan, V.,Njoroge, F.G. (deposition date: 2005-12-06, release date: 2007-01-09, Last modification date: 2024-03-13) |
Primary citation | Bogen, S.L.,Ruan, S.,Liu, R.,Agrawal, S.,Pichardo, J.,Prongay, A.,Baroudy, B.,Saksena, A.,Girijavallabhan, V.,Njoroge, F.G. Depeptidization efforts on P3-P2 a-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity. Bioorg.Med.Chem.Lett., 16:1621-1627, 2006 Cited by PubMed: 16387495DOI: 10.1016/j.bmcl.2005.12.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report