2DQT
High resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog
Replaces: 1HYXSummary for 2DQT
Entry DOI | 10.2210/pdb2dqt/pdb |
Related | 2DQU |
Descriptor | IMMUNOGLOBULIN 6D9, [1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL ESTER, ... (4 entities in total) |
Functional Keywords | catalytic antibody, ester hydrolysis, esterolytic, fab, immunoglobulin, immune system |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 48979.38 |
Authors | Kristensen, O.,Vassylyev, D.G.,Tanaka, F.,Ito, N.,Morikawa, K.,Fujii, I. (deposition date: 2006-05-30, release date: 2006-06-20, Last modification date: 2023-10-25) |
Primary citation | Oda, M.,Ito, N.,Tsumuraya, T.,Suzuki, K.,Sakakura, M.,Fujii, I. Thermodynamic and structural basis for transition-state stabilization in antibody-catalyzed hydrolysis J.Mol.Biol., 369:198-209, 2007 Cited by PubMed: 17428500DOI: 10.1016/j.jmb.2007.03.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report