2C77

EF-Tu complexed with a GTP analog and the antibiotic GE2270 A

Summary for 2C77

Entry DOI	10.2210/pdb2c77/pdb
Related	1D8T 1E9W 1OLN 2C78 2JQ7 2ZJP 3CF5
Related PRD ID	PRD_000225
Descriptor	ELONGATION FACTOR TU-B, THIOCILLIN GE2270, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
Functional Keywords	hydrolase-antibiotic complex, thiopeptide, antibiotic, antibacterial, thiazole, oxazole, hydrolase, gtpase, translation elongation factor, protein synthesis, nucleotide-binding, phosphorylation, hydrolase/antibiotic
Biological source	THERMUS THERMOPHILUS More
Total number of polymer chains	2
Total formula weight	46863.19
Authors	Parmeggiani, A.,Krab, I.M.,Okamura, S.,Nielsen, R.C.,Nyborg, J.,Nissen, P. (deposition date: 2005-11-18, release date: 2006-03-16, Last modification date: 2023-12-13)
Primary citation	Parmeggiani, A.,Krab, I.M.,Okamura, S.,Nielsen, R.C.,Nyborg, J.,Nissen, P. Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu. Biochemistry, 45:6846-6857, 2006 Cited by PubMed: 16734421 DOI: 10.1021/bi0525122 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation