2BDJ

Src kinase in complex with inhibitor AP23464

Summary for 2BDJ

• Entry DOI: 10.2210/pdb2bdj/pdb
• Related: 2BDF
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 3-[2-(2-CYCLOPENTYL-6-{[4-(DIMETHYLPHOSPHORYL)PHENYL]AMINO}-9H-PURIN-9-YL)ETHYL]PHENOL (3 entities in total)
• Functional Keywords: src kinase inhibitor, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane: P12931
• Total number of polymer chains: 1
• Total formula weight: 32445.29

Authors

Dalgarno, D.,Stehle, T.,Schelling, P.,Narula, S.,Sawyer, T. (deposition date: 2005-10-20, release date: 2006-10-24, Last modification date: 2023-08-23)

• Primary citation: Dalgarno, D.,Stehle, T.,Narula, S.,Schelling, P.,van Schravendijk, M.R.,Adams, S.,Andrade, L.,Keats, J.,Ram, M.,Jin, L.,Grossman, T.,MacNeil, I.,Metcalf III, C.,Shakespeare, W.,Wang, Y.,Keenan, T.,Sundaramoorthi, R.,Bohacek, R.,Weigele, M.,Sawyer, T.; Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.; Chem.Biol.Drug Des., 67:46-57, 2006; PubMed: 16492148; DOI: 10.1111/j.1747-0285.2005.00316.x

Experimental method

X-RAY DIFFRACTION (2.5 Å)