2ANT
THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE
Summary for 2ANT
Entry DOI | 10.2210/pdb2ant/pdb |
Descriptor | ANTITHROMBIN, 2-acetamido-2-deoxy-beta-D-allopyranose (3 entities in total) |
Functional Keywords | serpin, heparin, inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P01008 |
Total number of polymer chains | 2 |
Total formula weight | 98644.45 |
Authors | Skinner, R.,Abrahams, J.-P.,Whisstock, J.C.,Lesk, A.M.,Carrell, R.W.,Wardell, M.R. (deposition date: 1997-01-28, release date: 1997-06-16, Last modification date: 2023-08-09) |
Primary citation | Skinner, R.,Abrahams, J.P.,Whisstock, J.C.,Lesk, A.M.,Carrell, R.W.,Wardell, M.R. The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. J.Mol.Biol., 266:601-609, 1997 Cited by PubMed: 9067613DOI: 10.1006/jmbi.1996.0798 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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