2AF6
Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)
Summary for 2AF6
Entry DOI | 10.2210/pdb2af6/pdb |
Descriptor | Thymidylate synthase thyX, IODIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total) |
Functional Keywords | m.tuberculosis, thyx, fdts, tscp, flavin dependent thymidylate synthase, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 8 |
Total formula weight | 243699.20 |
Authors | Sampathkumar, P.,Turley, S.,Ulmer, J.E.,Rhie, H.G.,Sibley, C.H.,Hol, W.G. (deposition date: 2005-07-25, release date: 2005-10-04, Last modification date: 2023-11-15) |
Primary citation | Sampathkumar, P.,Turley, S.,Ulmer, J.E.,Rhie, H.G.,Sibley, C.H.,Hol, W.G. Structure of the Mycobacterium tuberculosis Flavin Dependent Thymidylate Synthase (MtbThyX) at 2.0A Resolution. J.Mol.Biol., 352:1091-1104, 2005 Cited by PubMed: 16139296DOI: 10.1016/j.jmb.2005.07.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
Download full validation report