2A5K

Crystal structures of SARS coronavirus main peptidase inhibited by an aza-peptide epoxide in space group P212121

Summary for 2A5K

• Entry DOI: 10.2210/pdb2a5k/pdb
• Related: 2A5A 2A5I
• Descriptor: 3C-like peptidase, (5S,8S,14R)-ETHYL 11-(3-AMINO-3-OXOPROPYL)-8-BENZYL-14-HYDROXY-5-ISOBUTYL-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,11-TETRAAZAPENTADECAN-15-OATE (3 entities in total)
• Functional Keywords: cysteine peptidase, 3c-like, n-finger, chymotrypsin-like fold, long loop, alpha-helical domain, dimer, catalytic dyad, specificity pockets, aza-peptide epoxide, substrate-like inhibitor, c-s covalent bond, epoxide stereochemistry, hydrolase
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 2
• Total formula weight: 69178.85

Authors

Lee, T.-W.,Cherney, M.M.,Huitema, C.,Liu, J.,James, K.E.,Powers, J.C.,Eltis, L.D.,James, M.N. (deposition date: 2005-06-30, release date: 2005-10-25, Last modification date: 2023-08-23)

• Primary citation: Lee, T.-W.,Cherney, M.M.,Huitema, C.,Liu, J.,James, K.E.,Powers, J.C.,Eltis, L.D.,James, M.N.; Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide; J.Mol.Biol., 353:1137-1151, 2005; PubMed: 16219322; DOI: 10.1016/j.jmb.2005.09.004

Experimental method

X-RAY DIFFRACTION (2.3 Å)