29OL
X-ray structure of the adduct formed upon reaction of the gold compound AF-Npx with lysozyme (Structure 2)
This is a non-PDB format compatible entry.
Summary for 29OL
| Entry DOI | 10.2210/pdb29ol/pdb |
| Descriptor | Lysozyme C, GOLD ION (3 entities in total) |
| Functional Keywords | gold, auranofin, naproxene, lysozyme, gold-protein interaction, lysine, hydrolase |
| Biological source | Gallus gallus (chicken) |
| Total number of polymer chains | 1 |
| Total formula weight | 15315.99 |
| Authors | Ferraro, G.,Merlino, A. (deposition date: 2026-03-26, release date: 2026-07-22, Last modification date: 2026-07-29) |
| Primary citation | Piroddu, D.,Famlonga, L.,Tolbatov, I.,Ferraro, G.,Chiaverini, L.,Merlino, A.,La Mendola, D.,Marrone, A.,Marzo, T. Tuning Au Reactivity Beyond Canonical Targets: Ligand-Driven Au(I) Metalation of Lysine Residues in Hen Egg White Lysozyme. Inorg.Chem., 65:16296-16304, 2026 Cited by PubMed Abstract: Au(I) complexes are widely investigated as therapeutic agents due to their high affinity for biological nucleophiles and protein targets. Here, the reactivity of an Auranofin (AF) derivative bearing naproxen as a ligand toward hen egg white lysozyme (HEWL) was investigated by a combined crystallographic and computational approach. Notably, the first observation of lysine metalation in HEWL by an Au complex is reported. The results highlight how ligand substitution can significantly affect Au(I) reactivity toward biomacromolecules, enabling noncanonical targeting and potentially impacting biological activity. PubMed: 42417613DOI: 10.1021/acs.inorgchem.6c01884 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.441 Å) |
Structure validation
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