28MR

X-ray structure of the adduct between human serum transferrin with Fe3+ bound at the C-lobe and diruthenium tetraacetate chloride

28MR の概要

• エントリーDOI: 10.2210/pdb28mr/pdb
• 分子名称: Serotransferrin, FE (III) ION, MALONATE ION, ... (8 entities in total)
• 機能のキーワード: human transferrin, diruthenium, iron, drug delivery, protein-metal interaction, metal transport
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75730.03

構造登録者

Ferraro, G.,Merlino, A. (登録日: 2026-02-08, 公開日: 2026-03-11, 最終更新日: 2026-03-18)

主引用文献

Banneville, A.S.,Ferraro, G.,D'Elia, R.,Cornaciu-Hoffmann, I.,Pica, A.,Merlino, A.
Ru and Rh binding sites in the structure of human serum transferrin with Fe 3+ bound at the C-lobe.
Dalton Trans, 55:4051-4056, 2026

PubMed Abstract: Ru and Rh binding sites in the structure of human serum transferrin with Fe bound at the C-lobe were identified by X-ray crystallography. Several His side chains and one Met are involved in the recognition of the metal ions by the protein.

PubMed: 41738634
DOI: 10.1039/d6dt00205f

実験手法

X-RAY DIFFRACTION (2.262 Å)