289D
TARGETING THE MINOR GROOVE OF DNA: CRYSTAL STRUCTURES OF TWO COMPLEXES BETWEEN FURAN DERIVATIVES OF BERENIL AND THE DNA DODECAMER D(CGCGAATTCGCG)2
Summary for 289D
Entry DOI | 10.2210/pdb289d/pdb |
Descriptor | DNA (5'-R(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2,5-BIS{[4-(N-CYCLOPROPYLDIAMINOMETHYL)PHENYL]}FURAN (3 entities in total) |
Functional Keywords | b-dna, double helix, complexed with drug, dna |
Total number of polymer chains | 2 |
Total formula weight | 7715.29 |
Authors | Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S. (deposition date: 1996-10-10, release date: 1996-12-17, Last modification date: 2024-04-03) |
Primary citation | Trent, J.O.,Clark, G.R.,Kumar, A.,Wilson, W.D.,Boykin, D.W.,Hall, J.E.,Tidwell, R.R.,Blagburn, B.L.,Neidle, S. Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2. J.Med.Chem., 39:4554-4562, 1996 Cited by PubMed: 8917643DOI: 10.1021/jm9604484 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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