24VM

Cryo-EM structure of the human wild-type KCNQ2/KCNQ3 heterotetramer (2:2 stoichiometry) in apo state (M2233 WT, without symmetry expansion)

Summary for 24VM

• Entry DOI: 10.2210/pdb24vm/pdb
• EMDB information: 69844
• Descriptor: Potassium voltage-gated channel subfamily KQT member 3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 2, (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, ... (4 entities in total)
• Functional Keywords: potassium channels, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 454555.28

Authors

Wang, Y.F.,Yang, H.,Qu, Y.N.,Shen, H.Z. (deposition date: 2026-03-22, release date: 2026-08-12)

• Primary citation: Wang, Y.,Yang, H.,Qu, Y.,Li, J.,Li, X.,Hou, W.,Wu, K.,Xie, G.,Wang, X.,Ye, Y.,Yang, H.,Shen, H.; Structural basis for heteromeric assembly and subthreshold activation of human M-channel; Vita, 2026; DOI: 10.15302/vita.2026.05.0032

Experimental method

ELECTRON MICROSCOPY (3.54 Å)