241D

EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)

241D の概要

• エントリーDOI: 10.2210/pdb241d/pdb
• 分子名称: DNA (5'-D(*CP*CP*CP*AP*AP*T)-3') (2 entities in total)
• 機能のキーワード: u-dna, quadruple helix, arallel-stranded tetraplex, base intercalated, mismatched, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3506.39

構造登録者

Berger, I.,Kang, C.,Fredian, A.,Ratliff, R.,Moyzis, R.,Rich, A. (登録日: 1995-12-07, 公開日: 1996-04-03, 最終更新日: 2024-02-14)

主引用文献

Berger, I.,Kang, C.,Fredian, A.,Ratliff, R.,Moyzis, R.,Rich, A.
Extension of the four-stranded intercalated cytosine motif by adenine.adenine base pairing in the crystal structure of d(CCCAAT).
Nat.Struct.Biol., 2:416-425, 1995

PubMed Abstract: The crystal structure of d(CCCAAT), refined at 2.0 A resolution, shows a four stranded molecule in which two parallel duplexes intercalate with opposite polarity, using cytosine.protonated cytosine base pairs. The intercalation motif in this structure is extended by adenine.adenine base pairs. Two topologically distinct broad grooves are found in the lath-like central part of the molecule with the phosphate groups on one side bent over towards each other, stabilized by bridging water molecules. At the 3' ends, two arrangements of intermolecular A.A.T base triplets are found, involving both asymmetric and symmetric A.A base pairs joined to thymine residues by Watson-Crick and reverse Hoogsteen base pairing, respectively.

PubMed: 7664099
DOI: 10.1038/nsb0595-416

実験手法

X-RAY DIFFRACTION (1.85 Å)