22XH

GII.23/24/25 noroviruses recognize glycans via a conventional glycan-binding site

Summary for 22XH

• Entry DOI: 10.2210/pdb22xh/pdb
• Descriptor: VP1, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose (3 entities in total)
• Functional Keywords: gii.25 p domain, h disaccharide, viral protein
• Biological source: Norovirus GII
• Total number of polymer chains: 2
• Total formula weight: 68738.66

Authors

Duan, Z.J.,Cong, X. (deposition date: 2026-01-27, release date: 2026-02-25, Last modification date: 2026-04-01)

Primary citation

Li, H.,Cong, X.,Sun, X.,Qi, J.,Li, X.,Jin, M.,Duan, Z.
GII.23/24/25 noroviruses recognize glycans via a conventional glycan-binding site.
Front Microbiol, 17:1767002-1767002, 2026

PubMed Abstract: Human noroviruses (HuNoVs) are genetically diverse RNA viruses that cause acute gastroenteritis, with genogroup II (GII) accounting for over 90% of global infections. Glycans, particularly histo-blood group antigens (HBGAs), have been identified as attachment factors or receptors for HuNoVs infection. However, the glycan-binding receptors of the later-identified GII genotypes GII.23/24/25 remain elusive.

PubMed: 41853721
DOI: 10.3389/fmicb.2026.1767002

Experimental method

X-RAY DIFFRACTION (1.6 Å)