205D
STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP
Summary for 205D
| Entry DOI | 10.2210/pdb205d/pdb |
| Descriptor | RNA (5'-R(*GP*GP*AP*CP*UP*UP*UP*GP*GP*UP*CP*C)-3') (2 entities in total) |
| Functional Keywords | a-rna, double helix, internal loop, mismatched, rna |
| Total number of polymer chains | 2 |
| Total formula weight | 7610.56 |
| Authors | Baeyens, K.J.,De Bondt, H.L.,Holbrook, S.R. (deposition date: 1995-04-14, release date: 1995-09-15, Last modification date: 2024-02-14) |
| Primary citation | Baeyens, K.J.,De Bondt, H.L.,Holbrook, S.R. Structure of an RNA double helix including uracil-uracil base pairs in an internal loop. Nat.Struct.Biol., 2:56-62, 1995 Cited by PubMed Abstract: The crystal structure of the RNA dodecamer 5'-GGACUUUGGUCC-3' has been determined from X-ray diffraction data to 2.6 A resolution. This oligomer forms an asymmetric double helix in the crystal. Four consecutive non-Watson-Crick base-pairs are formed in the middle of the duplex including the first intrahelical U-U (or T-T) pairs observed in an oligonucleotide crystal structure. Two different conformations of U-U pairs are observed in the context of the surrounding sequence. One of these pairs is highly twisted, allowing a bound water to bridge across strands in the major groove. The crystal packing illustrates a new form of RNA helix-helix interaction. PubMed: 7719854DOI: 10.1038/nsb0195-56 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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