205D

STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP

205D の概要

• エントリーDOI: 10.2210/pdb205d/pdb
• 分子名称: RNA (5'-R(*GP*GP*AP*CP*UP*UP*UP*GP*GP*UP*CP*C)-3') (2 entities in total)
• 機能のキーワード: a-rna, double helix, internal loop, mismatched, rna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7610.56

構造登録者

Baeyens, K.J.,De Bondt, H.L.,Holbrook, S.R. (登録日: 1995-04-14, 公開日: 1995-09-15, 最終更新日: 2024-02-14)

主引用文献

Baeyens, K.J.,De Bondt, H.L.,Holbrook, S.R.
Structure of an RNA double helix including uracil-uracil base pairs in an internal loop.
Nat.Struct.Biol., 2:56-62, 1995

PubMed Abstract: The crystal structure of the RNA dodecamer 5'-GGACUUUGGUCC-3' has been determined from X-ray diffraction data to 2.6 A resolution. This oligomer forms an asymmetric double helix in the crystal. Four consecutive non-Watson-Crick base-pairs are formed in the middle of the duplex including the first intrahelical U-U (or T-T) pairs observed in an oligonucleotide crystal structure. Two different conformations of U-U pairs are observed in the context of the surrounding sequence. One of these pairs is highly twisted, allowing a bound water to bridge across strands in the major groove. The crystal packing illustrates a new form of RNA helix-helix interaction.

PubMed: 7719854
DOI: 10.1038/nsb0195-56

実験手法

X-RAY DIFFRACTION (2.64 Å)