1ZZP

Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl

Summary for 1ZZP

DescriptorProto-oncogene tyrosine-protein kinase ABL1 (1 entity in total)
Functional Keywordsfour helix bundle, nuclear export signal, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor P00519
Total number of polymer chains1
Total molecular weight14150.12
Authors
Hantschel, O.,Wiesner, S.,Guttler, T.,Mackereth, C.D.,Rix, L.L.R.,Mikes, Z.,Dehne, J.,Gorlich, D.,Sattler, M.,Superti-Furga, G. (deposition date: 2005-06-14, release date: 2005-08-30, Last modification date: 2011-07-13)
Primary citation
Hantschel, O.,Wiesner, S.,Guttler, T.,Mackereth, C.D.,Rix, L.L.R.,Mikes, Z.,Dehne, J.,Gorlich, D.,Sattler, M.,Superti-Furga, G.
Structural Basis for the Cytoskeletal Association of Bcr-Abl/c-Abl.
Mol.Cell, 19:461-473, 2005
PubMed: 16109371 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2005.06.030
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers242.7%25.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures