1ZXT

Crystal Structure of A Viral Chemokine

1ZXT の概要

• エントリーDOI: 10.2210/pdb1zxt/pdb
• 分子名称: functional macrophage inflammatory protein 1-alpha homolog (2 entities in total)
• 機能のキーワード: chemokine fold, greek key motif, signaling protein
• 由来する生物種: Human herpesvirus 8
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 34700.26

構造登録者

Luz, J.G.,Yu, M.,Su, Y.,Wu, Z.,Zhou, Z.,Sun, R.,Wilson, I.A. (登録日: 2005-06-08, 公開日: 2005-08-30, 最終更新日: 2024-11-13)

主引用文献

Luz, J.G.,Yu, M.,Su, Y.,Wu, Z.,Zhou, Z.,Sun, R.,Wilson, I.A.
Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.
J.Mol.Biol., 352:1019-1028, 2005

PubMed Abstract: Viral macrophage inflammatory protein I (vMIP-I) is a chemokine encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous ligand is CCL1. The crystal structure of vMIP-I was determined at 1.7A for comparison with other chemokines, especially those that bind CCR8, such as vMIP-II from KSHV, a CCR8 antagonist and the closest homolog (40% identical). vMIP-I has a typical chemokine fold consisting of an extended N-terminal loop, followed by a three-stranded antiparallel beta-sheet and a C-terminal alpha-helix. The four molecules in the asymmetric unit comprise two MIP-1beta-like dimers. Electrostatic surface representations of CCR8-binding chemokines reveal only minor areas of correlating surface potential, which must be reconciled with promiscuity in receptor and glycosaminoglycan (GAG) binding. In addition, the biological relevance of chemokine oligomerization is examined by comparing the oligomeric states of all chemokine structures deposited to date in the RCSB PDB.

PubMed: 16140327
DOI: 10.1016/j.jmb.2005.08.011

実験手法

X-RAY DIFFRACTION (1.7 Å)