1ZUC

Progesterone receptor ligand binding domain in complex with the nonsteroidal agonist tanaproget

1ZUC の概要

• エントリーDOI: 10.2210/pdb1zuc/pdb
• 分子名称: Progesterone receptor, 5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: progesterone receptor, nonsteroidal agonist, tanaproget, progesterone, hormone, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus. Isoform A: Nucleus: P06401
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60282.56

構造登録者

Zhang, Z.,Olland, A.M.,Zhu, Y.,Cohen, J.,Berrodin, T.,Chippari, S.,Appavu, C.,Li, S.,Wilhem, J.,Chopra, R.,Fensome, A.,Zhang, P.,Wrobel, J.,Unwalla, R.J.,Lyttle, C.R.,Winneker, R.C. (登録日: 2005-05-30, 公開日: 2005-07-05, 最終更新日: 2023-08-23)

• 主引用文献: Zhang, Z.,Olland, A.M.,Zhu, Y.,Cohen, J.,Berrodin, T.,Chippari, S.,Appavu, C.,Li, S.,Wilhem, J.,Chopra, R.,Fensome, A.,Zhang, P.,Wrobel, J.,Unwalla, R.J.,Lyttle, C.R.,Winneker, R.C.; Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget; J.Biol.Chem., 280:28468-28475, 2005; PubMed: 15937332; DOI: 10.1074/jbc.M504144200

実験手法

X-RAY DIFFRACTION (2 Å)