1ZUA

Crystal Structure Of AKR1B10 Complexed With NADP+ And Tolrestat

Summary for 1ZUA

Related1C9W 1AH3 1ADS
DescriptorAldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, ... (4 entities in total)
Functional Keywordsalpha-beta barrel, aldo-keto reductase, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (Probable) O60218
Total number of polymer chains1
Total molecular weight37310.44
Authors
Gallego, O.,Ruiz, F.X.,Ardevol, A.,Dominguez, M.,Alvarez, R.,de Lera, A.R.,Rovira, C.,Farres, J.,Fita, I.,Pares, X. (deposition date: 2005-05-30, release date: 2006-11-07, Last modification date: 2011-07-13)
Primary citation
Gallego, O.,Ruiz, F.X.,Ardevol, A.,Dominguez, M.,Alvarez, R.,de Lera, A.R.,Rovira, C.,Farres, J.,Fita, I.,Pares, X.
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.
Proc.Natl.Acad.Sci.USA, 104:20764-20769, 2007
PubMed: 18087047 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0705659105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.157110.6%1.8%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution