1ZRK

Factor XI complexed with 3-hydroxypropyl 3-(7-amidinonaphthalene-1-carboxamido)benzenesulfonate

Summary for 1ZRK

• Entry DOI: 10.2210/pdb1zrk/pdb
• Related: 1ZHR
• Descriptor: Coagulation factor XI, SULFATE ION, 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE, ... (4 entities in total)
• Functional Keywords: serine protease, coagulation, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P03951
• Total number of polymer chains: 1
• Total formula weight: 27514.06

Authors

Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.J.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.,Strickler, J. (deposition date: 2005-05-19, release date: 2006-05-09, Last modification date: 2023-08-23)

• Primary citation: Guo, Z.,Bannister, T.,Noll, R.,Jin, L.,Rynkiewicz, M.J.,Bibbins, F.,Magee, S.,Gorga, J.,Babine, R.,Strickler, J.; Synthesis and Optimization of Potent and Selective Inhibitors for Human Factor XIa: Substituted Naphthamidine Series; To be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)