1ZP8

HIV Protease with inhibitor AB-2

Summary for 1ZP8

Entry DOI	10.2210/pdb1zp8/pdb
Descriptor	Pol polyprotein, [1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL (1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE (3 entities in total)
Functional Keywords	protease, retroviral, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	11468.59
Authors	Brik, A.,Alexandratos, J.N.,Elder, J.H.,Olson, A.J.,Wlodawer, A.,Goodsell, D.S.,Wong, C.H. (deposition date: 2005-05-16, release date: 2005-06-21, Last modification date: 2023-08-23)
Primary citation	Brik, A.,Alexandratos, J.,Lin, Y.C.,Elder, J.H.,Olson, A.J.,Wlodawer, A.,Goodsell, D.S.,Wong, C.H. 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors. Chembiochem, 6:1167-1169, 2005 Cited by PubMed: 15934050 DOI: 10.1002/cbic.200500101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation