1ZOM

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomimetic Inhibitor

1ZOM の概要

• エントリーDOI: 10.2210/pdb1zom/pdb
• 分子名称: Coagulation factor XI, SULFATE ION, (S)-2-(3-((R)-1-(4-BROMOPHENYL)ETHYL)UREIDO)-N-((S)-1-((S)-5-GUANIDINO-1-OXO-1-(THIAZOL-2-YL)PENTAN-2-YLAMINO)-3-METHYL-1-OXOBUTAN-2-YL)-5-UREIDOPENTANAMIDE, ... (4 entities in total)
• 機能のキーワード: fxia, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P03951
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27574.13

構造登録者

Lin, J.,Deng, H.,Jin, L.,Pandey, P.,Rynkiewicz, M.,Bibbins, F.,Cantin, S.,Quinn, J.,Magee, S.,Gorga, J. (登録日: 2005-05-13, 公開日: 2006-05-23, 最終更新日: 2023-08-23)

• 主引用文献: Lin, J.,Deng, H.,Jin, L.,Pandey, P.,Quinn, J.,Cantin, S.,Rynkiewicz, M.J.,Gorga, J.C.,Bibbins, F.,Celatka, C.A.,Nagafuji, P.,Bannister, T.D.,Meyers, H.V.,Babine, R.E.,Hayward, N.J.,Weaver, D.,Benjamin, H.,Stassen, F.,Abdel-Meguid, S.S.,Strickler, J.E.; Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.; J.Med.Chem., 49:7781-7791, 2006; PubMed: 17181160; DOI: 10.1021/jm060978s

実験手法

X-RAY DIFFRACTION (2.25 Å)