1ZKY

Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-3M and A Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide

Summary for 1ZKY

Entry DOI	10.2210/pdb1zky/pdb
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, ... (4 entities in total)
Functional Keywords	estrogen receptor, lbd, grip peptide, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	62792.27
Authors	Rajan, S.S.,Hsieh, R.W.,Sharma, S.K.,Hahm, J.B.,Nettles, K.W.,Greene, G.L. (deposition date: 2005-05-04, release date: 2006-05-09, Last modification date: 2023-08-23)
Primary citation	Hsieh, R.W.,Rajan, S.S.,Sharma, S.K.,Guo, Y.,Desombre, E.R.,Mrksich, M.,Greene, G.L. Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity. J.Biol.Chem., 281:17909-17919, 2006 Cited by PubMed: 16648639 DOI: 10.1074/jbc.M513684200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation