1ZHM

Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Benzamidine (S434A-T475A-K437 Mutant)

Summary for 1ZHM

Entry DOI	10.2210/pdb1zhm/pdb
Related	1ZHN 1ZHP 1ZHR 1ZJD
Descriptor	coagulation factor XI, BENZAMIDINE, GLUTATHIONE, ... (4 entities in total)
Functional Keywords	factor xi; benzamidine, hydrolase, blood clotting
Biological source	Homo sapiens (human)
Cellular location	Secreted: P03951
Total number of polymer chains	1
Total formula weight	27195.91
Authors	Jin, L.,Pandey, P.,Babine, R.E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E. (deposition date: 2005-04-26, release date: 2005-09-20, Last modification date: 2023-08-23)
Primary citation	Jin, L.,Pandey, P.,Babine, R.E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E. Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors. Acta Crystallogr.,Sect.D, 61:1418-1425, 2005 Cited by PubMed: 16204896 DOI: 10.1107/S0907444905024340 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation