1ZEF

structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor L-Phe

Summary for 1ZEF

Entry DOI	10.2210/pdb1zef/pdb
Related	1EW2 1ZEB 1ZED
Descriptor	Alkaline phosphatase, 2-acetamido-2-deoxy-beta-D-glucopyranose, PHENYLALANINE, ... (7 entities in total)
Functional Keywords	alkaline phosphatase, uncompetitive inhibitor, intermediate state, l-phe, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor, GPI-anchor: P05187
Total number of polymer chains	1
Total formula weight	53856.10
Authors	Llinas, P.,Stura, E.A.,Menez, A.,Kiss, Z.,Stigbrand, T.,Millan, J.L.,Le Du, M.H. (deposition date: 2005-04-18, release date: 2005-06-28, Last modification date: 2020-07-29)
Primary citation	Llinas, P.,Stura, E.A.,Menez, A.,Kiss, Z.,Stigbrand, T.,Millan, J.L.,Le Du, M.H. Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands. J.Mol.Biol., 350:441-451, 2005 Cited by PubMed: 15946677 DOI: 10.1016/j.jmb.2005.04.068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation