1ZE8

Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor

1ZE8 の概要

• エントリーDOI: 10.2210/pdb1ze8/pdb
• 分子名称: Carbonic anhydrase II, ZINC ION, 4-(HYDROXYMERCURY)BENZOIC ACID, ... (6 entities in total)
• 機能のキーワード: twisted beta-sheet, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29959.49

構造登録者

Menchise, V.,De Simone, G.,Alterio, V.,Di Fiore, A.,Pedone, C.,Scozzafava, A.,Supuran, C.T. (登録日: 2005-04-18, 公開日: 2005-10-18, 最終更新日: 2024-03-13)

• 主引用文献: Menchise, V.,De Simone, G.,Alterio, V.,Di Fiore, A.,Pedone, C.,Scozzafava, A.,Supuran, C.T.; Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II; J.Med.Chem., 48:5721-5727, 2005; PubMed: 16134940; DOI: 10.1021/jm050333c

実験手法

X-RAY DIFFRACTION (2 Å)