1ZBJ
Inferential Structure Determination of the Fyn SH3 domain using NOESY data from a 15N,H2 enriched protein
Summary for 1ZBJ
| Entry DOI | 10.2210/pdb1zbj/pdb |
| Related | 1NYF 1SHF |
| Descriptor | Proto-oncogene tyrosine-protein kinase FYN (1 entity in total) |
| Functional Keywords | transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane: P06241 |
| Total number of polymer chains | 1 |
| Total formula weight | 6738.28 |
| Authors | Rieping, W.,Habeck, M.,Nilges, M. (deposition date: 2005-04-08, release date: 2005-05-03, Last modification date: 2024-05-22) |
| Primary citation | Rieping, W.,Habeck, M.,Nilges, M. Inferential Structure Determination Science, 309:303-306, 2005 Cited by PubMed Abstract: Macromolecular structures calculated from nuclear magnetic resonance data are not fully determined by experimental data but depend on subjective choices in data treatment and parameter settings. This makes it difficult to objectively judge the precision of the structures. We used Bayesian inference to derive a probability distribution that represents the unknown structure and its precision. This probability distribution also determines additional unknowns, such as theory parameters, that previously had to be chosen empirically. We implemented this approach by using Markov chain Monte Carlo techniques. Our method provides an objective figure of merit and improves structural quality. PubMed: 16002620DOI: 10.1126/science.1110428 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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