1ZAG

HUMAN ZINC-ALPHA-2-GLYCOPROTEIN

Summary for 1ZAG

• Entry DOI: 10.2210/pdb1zag/pdb
• Descriptor: PROTEIN (ZINC-ALPHA-2-GLYCOPROTEIN), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: lipid mobilization factor, secreted mhc class i homolog
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 132606.04

Authors

Chirino, A.J.,Sanchez, L.M.,Bjorkman, P.J. (deposition date: 1999-02-02, release date: 1999-03-31, Last modification date: 2023-12-27)

Primary citation

Sanchez, L.M.,Chirino, A.J.,Bjorkman, P.
Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.
Science, 283:1914-1919, 1999

PubMed Abstract: Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 angstrom crystal structure of ZAG resembles a class I major histocompatibility complex (MHC) heavy chain, but ZAG does not bind the class I light chain beta2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a nonpeptidic compound that may be implicated in lipid catabolism under normal or pathological conditions.

PubMed: 10206894
DOI: 10.1126/science.283.5409.1914

Experimental method

X-RAY DIFFRACTION (2.8 Å)