1ZAG

HUMAN ZINC-ALPHA-2-GLYCOPROTEIN

1ZAG の概要

• エントリーDOI: 10.2210/pdb1zag/pdb
• 分子名称: PROTEIN (ZINC-ALPHA-2-GLYCOPROTEIN), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: lipid mobilization factor, secreted mhc class i homolog
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132606.04

構造登録者

Chirino, A.J.,Sanchez, L.M.,Bjorkman, P.J. (登録日: 1999-02-02, 公開日: 1999-03-31, 最終更新日: 2024-11-13)

主引用文献

Sanchez, L.M.,Chirino, A.J.,Bjorkman, P.
Crystal structure of human ZAG, a fat-depleting factor related to MHC molecules.
Science, 283:1914-1919, 1999

PubMed Abstract: Zn-alpha2-glycoprotein (ZAG) is a soluble protein that is present in serum and other body fluids. ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. The 2.8 angstrom crystal structure of ZAG resembles a class I major histocompatibility complex (MHC) heavy chain, but ZAG does not bind the class I light chain beta2-microglobulin. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. Instead of a peptide, the ZAG groove contains a nonpeptidic compound that may be implicated in lipid catabolism under normal or pathological conditions.

PubMed: 10206894
DOI: 10.1126/science.283.5409.1914

実験手法

X-RAY DIFFRACTION (2.8 Å)