1ZAF

Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one

Summary for 1ZAF

Entry DOI	10.2210/pdb1zaf/pdb
Descriptor	Estrogen receptor beta, Nuclear receptor coactivator 1, 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE, ... (4 entities in total)
Functional Keywords	estrogen receptor, estrogen receptor beta, er-beta, er, estrogen, nuclear receptor, transcription factor, agonist, transcription-transferase complex, transcription/transferase
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q92731 Nucleus (By similarity): Q15788
Total number of polymer chains	4
Total formula weight	57221.41
Authors	McDevitt, R.E.,Malamas, M.S.,Manas, E.S.,Unwalla, R.J.,Xu, Z.B.,Miller, C.P.,Harris, H.A. (deposition date: 2005-04-06, release date: 2006-04-11, Last modification date: 2024-02-14)
Primary citation	McDevitt, R.E.,Malamas, M.S.,Manas, E.S.,Unwalla, R.J.,Xu, Z.B.,Miller, C.P.,Harris, H.A. Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones Bioorg.Med.Chem.Lett., 15:3137-3142, 2005 Cited by PubMed Abstract: The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity. PubMed: 15876535 DOI: 10.1016/j.bmcl.2005.04.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation