1Z71
thrombin and P2 pyridine N-oxide inhibitor complex structure
Summary for 1Z71
Entry DOI | 10.2210/pdb1z71/pdb |
Descriptor | thrombin, Hirudin IIIB', L17, ... (4 entities in total) |
Functional Keywords | thrombin inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 Secreted: P28511 |
Total number of polymer chains | 2 |
Total formula weight | 35011.76 |
Authors | Nantermet, P.G.,Burgey, C.S.,Robinson, K.A.,Pellicore, J.M.,Newton, C.L.,Deng, J.Z.,Lyle, T.A.,Selnick, H.G.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Miller-Stein, C.,White, R.B.,Wong, B.,McMasters, D.R.,Wallace, A.A.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P. (deposition date: 2005-03-23, release date: 2005-05-17, Last modification date: 2017-10-11) |
Primary citation | Nantermet, P.G.,Burgey, C.S.,Robinson, K.A.,Pellicore, J.M.,Newton, C.L.,Deng, J.Z.,Selnick, H.G.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Miller-Stein, C.,White, R.B.,Wong, B.,McMasters, D.R.,Wallace, A.A.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P.,Lyle, T.A. P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold BIOORG.MED.CHEM.LETT., 15:2771-2775, 2005 Cited by PubMed: 15911253DOI: 10.1016/j.bmcl.2005.03.110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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