1Z71

thrombin and P2 pyridine N-oxide inhibitor complex structure

1Z71 の概要

• エントリーDOI: 10.2210/pdb1z71/pdb
• 分子名称: thrombin, Hirudin IIIB', L17, ... (4 entities in total)
• 機能のキーワード: thrombin inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734; Secreted: P28511
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35011.76

構造登録者

Nantermet, P.G.,Burgey, C.S.,Robinson, K.A.,Pellicore, J.M.,Newton, C.L.,Deng, J.Z.,Lyle, T.A.,Selnick, H.G.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Miller-Stein, C.,White, R.B.,Wong, B.,McMasters, D.R.,Wallace, A.A.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P. (登録日: 2005-03-23, 公開日: 2005-05-17, 最終更新日: 2017-10-11)

• 主引用文献: Nantermet, P.G.,Burgey, C.S.,Robinson, K.A.,Pellicore, J.M.,Newton, C.L.,Deng, J.Z.,Selnick, H.G.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Miller-Stein, C.,White, R.B.,Wong, B.,McMasters, D.R.,Wallace, A.A.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P.,Lyle, T.A.; P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold; BIOORG.MED.CHEM.LETT., 15:2771-2775, 2005; PubMed: 15911253; DOI: 10.1016/j.bmcl.2005.03.110

実験手法

X-RAY DIFFRACTION (1.8 Å)