1Z6J

Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor

1Z6J の概要

• エントリーDOI: 10.2210/pdb1z6j/pdb
• 分子名称: Coagulation factor VII, Tissue factor, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: blood coagulation, serine protease, thrombosis, gla, pyrazinone, benzamidine, tissue factor, cofactor, enzyme inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 69040.68

構造登録者

Schweitzer, B.A.,Neumann, W.L.,Rahman, H.K.,Kusturin, C.L.,Sample, K.R.,Poda, G.I.,Kurumbail, R.G.,Stevens, A.M.,Stegeman, R.A.,Stallings, W.C. (登録日: 2005-03-22, 公開日: 2005-05-03, 最終更新日: 2019-07-24)

• 主引用文献: Schweitzer, B.A.,Neumann, W.L.,Rahman, H.K.,Kusturin, C.L.,Sample, K.R.,Poda, G.I.,Kurumbail, R.G.,Stevens, A.M.,Stegeman, R.A.,Stallings, W.C.,South, M.S.; Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa.; Bioorg.Med.Chem.Lett., 15:3006-3011, 2005; PubMed: 15913999; DOI: 10.1016/j.bmcl.2005.04.037

実験手法

X-RAY DIFFRACTION (2 Å)