1Z62
Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites
Summary for 1Z62
Entry DOI | 10.2210/pdb1z62/pdb |
Related | 2AMV |
Descriptor | Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID, ... (4 entities in total) |
Functional Keywords | glycogenolysis, type 2 diabetes, transferase |
Biological source | Oryctolagus cuniculus (rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 98544.29 |
Authors | Kosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G. (deposition date: 2005-03-21, release date: 2006-03-07, Last modification date: 2011-07-13) |
Primary citation | Kosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G. Indirubin-3'-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites LETT.DRUG DES.DISCOVERY, 2:377-390, 2005 Cited by |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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