1Z62

Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites

1Z62 の概要

• エントリーDOI: 10.2210/pdb1z62/pdb
• 関連するPDBエントリー: 2AMV
• 分子名称: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98544.29

構造登録者

Kosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G. (登録日: 2005-03-21, 公開日: 2006-03-07, 最終更新日: 2011-07-13)

• 主引用文献: Kosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G.; Indirubin-3'-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites; LETT.DRUG DES.DISCOVERY, 2:377-390, 2005

実験手法

X-RAY DIFFRACTION (1.9 Å)