1Z3G

Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8

1Z3G の概要

• エントリーDOI: 10.2210/pdb1z3g/pdb
• 分子名称: 2A8 Fab Light Chain, 2A8 Fab Heavy Chain, ookinete surface protein Pvs25 (3 entities in total)
• 機能のキーワード: 2a8 fab, pvs25, immune system-cell adhesion complex, immune system/cell adhesion
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 134212.03

構造登録者

Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N. (登録日: 2005-03-12, 公開日: 2005-12-06, 最終更新日: 2024-10-30)

主引用文献

Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N.
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms
Nat.Struct.Mol.Biol., 13:90-91, 2006

PubMed Abstract: P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.

PubMed: 16327807
DOI: 10.1038/nsmb1024

実験手法

X-RAY DIFFRACTION (3.3 Å)