1Z3F

Structure of ellipticine in complex with a 6-bp DNA

Summary for 1Z3F

• Entry DOI: 10.2210/pdb1z3f/pdb
• Descriptor: 5'-D(*CP*GP*AP*TP*CP*G)-3', ELLIPTICINE, COBALT (II) ION, ... (4 entities in total)
• Functional Keywords: anticancer, dna binding, drug design, ellipticine, intercalator, dna
• Total number of polymer chains: 2
• Total formula weight: 4289.86

Authors

Canals, A.,Purciolas, M.,Aymami, J.,Coll, M. (deposition date: 2005-03-12, release date: 2005-07-19, Last modification date: 2024-02-14)

Primary citation

Canals, A.,Purciolas, M.,Aymami, J.,Coll, M.
The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.
Acta Crystallogr.,Sect.D, 61:1009-1012, 2005

PubMed Abstract: Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.

PubMed: 15983425
DOI: 10.1107/S0907444905015404

Experimental method

X-RAY DIFFRACTION (1.5 Å)