1Z3F

Structure of ellipticine in complex with a 6-bp DNA

1Z3F の概要

• エントリーDOI: 10.2210/pdb1z3f/pdb
• 分子名称: 5'-D(*CP*GP*AP*TP*CP*G)-3', ELLIPTICINE, COBALT (II) ION, ... (4 entities in total)
• 機能のキーワード: anticancer, dna binding, drug design, ellipticine, intercalator, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4289.86

構造登録者

Canals, A.,Purciolas, M.,Aymami, J.,Coll, M. (登録日: 2005-03-12, 公開日: 2005-07-19, 最終更新日: 2024-02-14)

主引用文献

Canals, A.,Purciolas, M.,Aymami, J.,Coll, M.
The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.
Acta Crystallogr.,Sect.D, 61:1009-1012, 2005

PubMed Abstract: Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.

PubMed: 15983425
DOI: 10.1107/S0907444905015404

実験手法

X-RAY DIFFRACTION (1.5 Å)